Shingo Matsumoto, Ph.D.

Associate Professor (Electron & Nuclear Magnetic Resonance Imaging)

Web page of 13C-MRI group https://hp13c-mri.com

Research interests

Prof. Shingo Matsumoto leads a research team, which focuses on development of metabolic imaging technique using a “hyperpolarized” 13C magnetic resonance imaging (MRI). Any kinds of diseases accompany some metabolic alteration at the region of disease. Proteins translated from genes with an innate and/or acquired mutation catalyze abnormal metabolic reactions, resulting in various diseases including cancer. If such metabolic reaction in one’s body can be detected in a non-invasive manner, it helps early detection of the disease and optimization of treatment strategy. Hyperpolarized 13C MRI is an up-to-date technique. By enhancing NMR signal of a stable isotope 13C over 10,000 times, it enables non-invasive real time imaging of metabolic reaction of 13C labeled chemicals within the body. Prof. Matsumoto’s research team is developing novel imaging techniques to detect various diseases and genetic alterations using the hyperpolarized 13C MRI.

 

Mailing Address

Division of Bioengineering and Bioinformatics
Graduate School of Information Science and Technology
Hokkaido University
North 14, West 9, Kita-ku
Sapporo 060-0814
Japan

Office M-208
Phone +81-11-706-6789, Fax +81-11-706-6802
E-mail: smatsumoto *at* ist *dot* hokudai *dot* ac *dot* jp

Education

  • 2005 Ph.D. (Pharmaceutical Science), Kyushu University, Fukuoka, Japan
  • 2002 M.S. (Pharmaceutical Science), Kyushu University, Fukuoka, Japan
  • 2000 B.S. (Pharmaceutical Science), Kyushu University, Fukuoka, Japan

License

  • 2001 License of Pharmacist

Professional Career/Appointments

  • 2015/2 Associate Professor, Division of Bioengineering and Bioinformatics, Graduate School of Information Science and Technology, Hokkaido University, Japan
  • 2014/6 Staff Scientist, Radiation Biology Branch, National Cancer Institute, NIH, Bethesda, MD 20892, USA
  • 2012/12 Research Fellow, Same as above, NCI/NIH
  • 2005/12 Postdoctoral Fellow, Same as above, NCI/NIH
  • 2003/4 JSPS Research Fellow (DC2, PD), The Japan Society for the Promotion of Science for Young Scientists

Honors

  • 2003 JSPS Research Fellowship for Young Scientists (Japan)
  • 2008 Exceptional Stipend Award in Center for Cancer Research (NIH)
  • Travel Stipend Award in World Molecular Imaging Congress (France)
  • Young Investigator Award in EPR2008 (Biomedical Redox Navigation) (Japan)

Patents

  • Matsumoto S, Saito K, Krishna MC, Mitchell JB, and Gillies RJ. Transient hypoxia inducers and their use. U.S Patent filed, No. 14/112,906 dated Oct. 13, 2013.
  • Subramanian S, Devasahayam N, Matsumoto S, Mitchell JB, Krishna MC, and Cook JA. Quantitative oxygen imaging systems and methods using echo-based single point imaging. E-250-2008, Patent filed, No. 61/200,579 dated Nov. 29, 2008.

Editorial Board

  • Advances in Medicine

Ad hoc reviewer

  • Cytokine (2009, 2011, 2011, 2015 x2)
  • Mol. Can. Ther. (2012)
  • ISOTT Proceeding (2013 x2)
  • Molecular Imaging (2013, 2014)
  • Clin. Cancer Res. (2014)
  • Biochim. Biophys. Acta (2014)

Recent publications

  1. Saito K, Matsumoto S, Takakusagi Y, Matsuo M, Morris HD, Lizak MJ, Munasinghe JP, Devasahayam N, Subramanian S, Mitchell JB, Krishna MC. 13C-MR spectroscopic imaging with hyperpolarized [1-13C]pyruvate detects early response to radiotherapy in SCC tumors and HT-29 tumors. Clinical Cancer Research, accepted (2015, Feb 11)
  2. Sourbier C, Ricketts CJ, Matsumoto S, Crooks DR, Liao PJ, Mannes PZ, Yang Y, Wei MH, Srivastava G, Ghosh S, Chen V, Vocke CD, Merino M, Srinivasan R, Krishna MC, Mitchell JB, Pendergast AM, Rouault TA, Neckers L, Linehan WM. Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase- deficient cancer. Cancer Cell, Vol. 26, No. 6, pp. 840-850 (2014)
  3. Matsumoto S, Saito K, Takakusagi Y, Matsuo M, Munasinghe JP, Morris HD, Lizak MJ, Merkle H, Yasukawa K, Devasahayam N, Suburamanian S, Mitchell JB, Krishna MC. In vivo imaging of tumor physiological, metabolic, and redox changes in response to the anti-angiogenic agent sunitinib: longitudinal assessment to identify transient vascular renormalization. Antioxidant & Redox Signaling, Vol. 21, No. 8, pp. 1145-1155 (2014)
  4. Matsumoto S, Saito K, Yasui H, Morris HD, Munasinghe JP, Lizak M, Merkle H, Ardenkjaer-Larsen JH, Choudhuri R, Devasahayam N, Subramanian S, Koretsky AP, Mitchell JB, Krishna MC. EPR oxygen imaging and hyperpolarized 13C MRI of pyruvate metabolism as noninvasive biomarkers of tumor treatment response to a glycolysis inhibitor 3-bromopyruvate. Magnetic Resonance in Medicine, Vol. 69, No. 5, pp. 1443-1450 (2013)
  5. Matsumoto S, Batra S, Saito K, Yasui H, Choudhuri R, Gadisetti C, Subramanian S, Devasahayam N, Munasinghe JP, Mitchell JB, Krishna MC. Cancer Research, Vol. 71, No. 20, pp. 6350-6359 (2011)
  6. Matsumoto S, Yasui H, Mitchell JB, Krishna MC. Imaging cycling tumor hypoxia. Cancer Research, Vol. 70, No. 24, pp. 10019-10023 (2010)
  7. Rajesh M, Mukhopadhyay P, Bátkai S, Patel V, Saito K, Matsumoto S, Kashiwaya Y, Horváth B, Mukhopadhyay B, Becker L, Haskó G, Liaudet L, Wink DA, Veves A, Mechoulam R, Pacher P. Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy. Journal of The American College of Cardiology, Vol. 56, No. 25, pp. 2115-2125 (2010)
  8. Yasui H, Matsumoto S, Devasahayam N, Munasinghe JP, Choudhuri R, Saito K, Subramanian S, Mitchell JB, Krishna MC. Low-field magnetic resonance imaging to visualize chronic and cycling hypoxia in tumor-bearing mice. Cancer Research, Vol. 70, No. 16, pp. 6427-6436 (2010)
  9. Matsumoto S, Yasui H, Batra S, Kinoshita Y, Bernardo M, Munasinghe JP, Utsumi H, Choudhuri R, Devasahayam N, Subramanian S, Mitchell JB, Krishna MC. Simultaneous imaging of tumor oxygenation and microvascular permeability using Overhauser enhanced MRI. Proc Natl Acad Sci USA, Vol. 106, No. 42, pp. 17898-17903 (2009)
  10. Matsumoto S, Hyodo F, Subramanian S, Devasahayam N, Munasinghe J, Hyodo E, Gadisetti C, Cook JA, Mitchell JB, Krishna MC. Low-field paramagnetic resonance imaging of tumor oxygenation and glycolytic activity in mice. The Journal of Clinical Investigation, Vol. 118, No. 5, pp. 1965-1973 (2008)