Publication

• Takahiro Kotani, Tomohiro Matsuo, Megumi Yokobori, Yosuke Tsuboyama, Yuki Miyata, Yuki Fujii, Kaori Kuribayashi-Shigetomi, Takaharu Okajima*, Mapping single-cell rheology of ascidian embryos in the cleavage stages using AFM, bioRxiv (2024). [paper]
• Toki Kaneshima, Masaki Ogawa, Takayoshi Yamamoto, Yosuke Tsuboyama, Yuki Miyata, Takahiro Kotani, Takaharu Okajima, Tatsuo Michiue*, Enhancement of neural crest formation by mechanical force in Xenopus development, International Journal of Developmental Biology 68, 25-37 (2024). [paper]
• Takahiro Kotani, Yuki Miyata, Yosuke Tsuboyama, Yuki Fujii, Takaharu Okajima*, Local Intracellular stiffening of ascidian embryo in cleavage developmental stage observed by atomic force microscopy, Japanese Journal of Applied Physics 63, 04SP64 (2024).[paper]
• Yuki Miyata, Feng-Yueh Chan, Takayuki Uchihashi, Takaharu Okajima*, Compressed sensing reconstruction of cell mechanical images obtained from atomic force microscopy, Japanese Journal of Applied Physics, 63, 04SP46 (2024).[paper]
• K. Shigemura, K. Kuribayashi-Shigetomi, R. Tanaka, H. Yamasaki, and T. Okajima*, Mechanical properties of epithelial cells in domes investigated using atomic force microscopy, Frontiers in Cell and Developmental Biology 11, 1245296 (2023). [paper]
• T. Okajima*, K. Kuribayashi-Shigetomi, ,Atomic force microscopy for investigating cell and tissue mechanics as heterogeneous and hierarchical materials, Journal of Biomechanical Science and Engineering 18, 23-00339 (2023). [paper]
• H. Tsuru, C. Yoshihara, H. Suginobe, M. Matsumoto, Y. Ishii, J. Narita , R. Ishii, R. Wang, A. Ueyama, K. Ueda, M. Hirose, K. Hashimoto, H. Nagano, R. Tanaka, T. Okajima, K. Ozono, H. Ishida* ,Pathogenic Roles of Cardiac Fibroblasts in Pediatric Dilated Cardiomyopathy, Journal of the American Heart Association 12,e029676 (2023). [paper]
• M. Matsumoto#, H. Tsuru#, H. Suginobe#, J. Narita, R. Ishii, M. Hirose, K. Hashimoto, R. Wang, C. Yoshihara, A. Ueyama, R. Tanaka, K. Ozono, T. Okajima*, H. Ishida* (# equal contribution), Atomic force microscopy identifies the alteration of rheological properties of the cardiac fibroblasts in idiopathic restrictive cardiomyopathy,PLoS ONE 17, e0275296 (2022). [paper]
• Y. Fujii, W.C. Koizumi, T. Imai, M. Yokobori, T. Matsuo, K. Oka, K. Hotta*, T. Okajima*, Spatiotemporal dynamics of single cell stiffness in the early developing ascidian chordate embryo, Communications Biology 4, 341 (2021). [paper]
• Y. M. Efremov*, T. Okajima, A. Raman, Measuring viscoelasticity of soft biological samples using atomic force microscopy, Soft Matter 16, 64-81(2020).[paper]
• R. Tanaka, M. Sawano, Y. Fujii, K. Kuribayashi-Shigetomi, A. Subagyo, K. Sueoka, T. Okajima*, Relationship between rheological properties and actin filaments of single cells investigated by atomic force microscopy, Japanese Journal of Applied Physics (2020).[paper]
• K. Toyota#, R. Tanaka#, T. Okajima* (# equal contribution), Stiffness of brewers’ yeast under ethanol stress investigated by atomic force microscopy, Japanese Journal of Applied Physics 59, SN1005(2020).[paper]
• Y. Fujii, Y. Ochi, M. Tuchiya, M. Kajita, Y. Fujita, Y. Ishimoto, T. Okajima*, Spontaneous spatial correlation of elastic modulus in jammed epithelial monolayers observed by AFM, Biophysical Journal (2019).[paper]
• H. Nishino*, M. Domae, T. Takanashi, T. Okajima, Cricket tympanal organ revisited: morphology, development, and possible functions of the adult-specific chitin core beneath the anterior tympanal membrane, Cell and Tissue Research (2019).
• Y. Fujii, T. Okajima* , Calibrating the Young’s modulus of soft materials with surface tilt angle measured by atomic force microscopy, AIP Advances 9, 015028 (2019).[paper]
• M. Tanaka#, Y. Fujii#, K. Hirano, T. Higaki, A. Nagasaki, R. Ishikawa, T. Okajima, K. Katoh* (# equal contribution), Fascin in lamellipodia contributes to cell elasticity by controlling the orientation of filamentous actin, Genes to Cells (2019). [paper]
• A. Tanaka*, Y. Fujii, N. Kasai, T. Okajima, H. Nakashima, Regulation of Neuritogenesis in Hippocampal Neurons using Stiffness of Extracellular Microenvironment. PLOS ONE 13, e0191928(2018) [paper]
• Q. He, T. Okajima, H. Onoe, A. Subagyo, K. Sueoka, K. Kuribayashi-Shigetomi*, Origami-based self-folding of co-cultured NIH/3T3 and HepG2 cells into 3D microstructures, Scientific Reports 8, 4556 (2018) [paper]
• P.G. Cai, R. Takahashi, K. Kuribayashi-Shigetomi, A. Subagyo, K. Sueoka, J. M. Maloney, K. J. Van Vliet, T. Okajima*, Temporal Variation in Single-Cell Power-Law Rheology Spans the Ensemble Variation of Cell Population, Biophysical Journal 113, 671-678 (2017) . [paper] (This paper was highlighted in BJ.)
• S.‑O. Kim, J. Kim, T. Okajima and N.‑J. Cho*, Mechanical properties of paraformaldehyde‑treated individual cells investigated by atomic force microscopy and scanning ion conductance microscopy. Nano Convergence 4, 5 (2017).[paper]
• R. Takahashi, T. Okajima*, Comparison between power-law rheological parameters of living cells in frequency and time domains measured by atomic force microscopy. Japanese Journal of Applied Physics 55, 08NB22 (2016).[paper]]
• T. Okajima，Nanorheology of Living Cells (Chapter 13, The World of Nano-Biomechanics, A. Ikai, Elsevier） (2016)
• R. Takahashi, T. Okajima*, Mapping power-law rheology of living cells using multi-frequency force modulation atomic force microscopy, Applied Physics Letters 107, 173702 (2015).[paper]
• A. Tanaka*, R. Tanaka, N. Kasai, S. Tsukada, T. Okajima, K. Sumitomo, Time-lapse imaging of morphological changes in a single neuron during the early stages of apoptosis using scanning ion conductance microscopy, Journal of Structural Biology 191, 32–38 (2015). [paper]
• P.G. Cai, T. Okajima*, Precision of cell-to-cell variation in power-law rheology characterized by atomic force microscopy, Japanese Journal of Applied Physics 54, 037001(2015)[paper]
• T. Okajima, Atomic Force Microscopy: Imaging and Rheology of Living Cells (Nano/Micro Science and Technology in Biorheology: Principles, Methods, and Applications Chapter 15 (387-414), Springer, 2015)[book]
• K. Kuribayashi-Shigetomi, R. Takahashi, A. Subagyo, K. Sueoka, T. Okajima, High-throughput measurements of single cell rheology by atomic force microscopy (Hyper Bio Assembler for 3D Cellular Systems, Chapter 4 (57-67), Springer, 2015)[book]
• M. Kajita, K. Sugimura, A. Ohoka, J. Burden, H. Suganuma, M. Ikegawa, T. Shimada, T. Kitamura, M. Shindoh, S. Ishikawa, S. Yamamoto, S. Saitoh, Y. Yako, R. Takahashi, T. Okajima, J. Kikuta, Y. Maijima, M. Ishii, M. Tada, and Y. Fujita*, Filamin acts as a key regulator in epithelial defence against transformed cells, Nature Communications 5, 4428(2014)[paper]
• R.Takahashi, S. Ichikawa, A. Subagyo, K. Sueoka, and T. Okajima*, Atomic force microscopy measurements of mechanical properties of single cells patterned by microcontact printing, Advanced Robotics 28, 449-455(2014) [paper]
• P.G. Cai, Y. Mizutani, M. Tsuchiya, J. M. Maloney, B. Fabry, K. J. Van Vliet, T. Okajima*, Quantifying Cell-to-Cell Variation in Power-Law Rheology, Biophysical Journal 105 (2013) 1093-1102. [paper]
• Y. Mizutani, M.-H. Choi, S.-J. Cho, T. Okajima*, Nanoscale fluctuations on epithelial cell surfaces investigated by scanning ion conductance microscopy, Applied Physics Letters 102 (2013) 173703 (4pages).[paper]
• T. Okajima*, Atomic Force Microscopy for the Examination of Single Cell Rheology (Review), Current Pharmaceutical Biotechnology, 13(2012)2623-2631.
• Y. Mizutani, K. Kawahara, T. Okajima*, Effect of Isoproterenol on Local Contractile Behaviors of Rat Cardiomyocytes Measured by Atomic Force Microscopy Current Pharmaceutical Biotechnology 13(2012)2599-2603.
• A. Okada, Y. Mizutani, A. Subagyo, H. Hosoi, M. Nakamura, K. Sueoka, K. Kawahara, T. Okajima*,Direct observation of dynamic force propagation between focal adhesions of cells on microposts by atomic force microscopy. Appl. Phys. Lett. 99 (2011) 263703. [selected for the January 1, 2012 issue of Virtual Journal of Biological Physics Research]
• Kunugi, S., Iwabuchi, S., Matsuyama, D., Okajima, T. and Kawahara*, K.Negative-feedback regulation of ATP release: ATP release from cardiomyocytes is strictly regulated during ischemia. Biochemical and Biophysical Research Communications, 416:409-415, 2011.
• Niikura K*, Nambara K, Okajima T, Kamitani R, Aoki S, Matsuo Y, Ijiro K.
  Artificial polymeric receptors on the cell surface promote the efficient cellular uptake of quantum dots, Org Biomol Chem. 9(2011)5787-92.
• A. Miyaoka, Y. Mizutani, M. Tsuchiya, K. Kawahara, T. Okajima* Rheological Properties of Growth-Arrested Fibroblast Cells under Serum Starvation Measured by Atomic Force Microscopy. Jpn. J. Appl. Phys. 50 (2011)08LB16(4pages).
• K. Niikura*, K. Nambara, T. Okajima, Y. Matsuo and K. Ijiro, Influence of Hydrophobic Structures on the Plasma Membrane Permeability of Lipidlike Molecules Langmuir 26 (2010) 9170
• S. Hiratsuka, Y. Mizutani, P.G. Cai, M. Tsuchiya, H. Tokumoto, K. Kawahara, T. Okajima*, Statistics of Single Cell Mechanics Investigated by Atomic Force Microscopy The 2010 MRS Spring Meeting Symposium U proceedings in press.
• S. Hiratsuka, Y. Mizutani, M. Tsuchiya, K. Kawahara, H. Tokumoto and T. Okajima*,The number distribution of complex shear modulus of single cells measured by atomic force microscopy,Ultramicroscopy Volume 109, Issue 8, July 2009, Pages 937-941.
• R. Kamitani, K. Niikura*, T. Okajima, Y. Matsuo, K. Ijiro*, Design of cell-surface-retained polymers for artificial ligand display, Chembiochem 10(2009)230-233.
• S. Hiratsuka, Y. Mizutani, A. Toda, N. Fukushima, K. Kawahara, H. Tokumoto and T. Okajima*, Power-Law Stress and Creep Relaxations of Single Cells Measured by Colloidal ProbeAtomic Force Microscopy Jpn. J. Appl. Phys. 48 (2009)08JB14-1-4
• K. Shikinaka, H. Kwon, A. Kakugo, H. Furukawa, Y. Osada, J.P. Gong*, Y. Aoyama, H. Nishioka, H. Jinnai, T. Okajimaa, “Observation of the Three-Dimensional Structure of Actin Bundles formed with Polycations”, Biomacromolecules, 9, 537-542 (2008).
• Y. Tanaka*, Y. Kawauchi, T. Kurokawa, H. Furukawa, T. Okajima, and J. P. Gong, “Localized Yielding around Crack Tips of Double-network Gels”, Macromol. Rapid Commun., 29, 1514-1520 (2008).
• H. Yamamura, K. Kimura, T. Okajima, H. Tokumoto, Y. Watamabe*, “Affinity of Functional Groups for Membrane Surfaces: Implications for Physically Irreversible Fouling”, Environ. Sci. Technol. 42(2008) 5310-5315.
• Y. Mizutani, M. Tsuchiya, S. Hiratsuka, K. Kawahara, H. Tokumoto and T. Okajima*, “Elasticity of Living Cells on a Microarray during the Early Stages of Adhesion Measured by Atomic Force Microscopy”, Jpn. J. Appl. Phys. 47(2008)6177-6180.
• T. Okajima*, M. Tanaka, S. Tsukiyama, T. Kadowaki, S. Yamamoto, M. Shimomura and H. Tokumoto, ” Stress Relaxation Measurement of Fibroblast Cells with Atomic Force Microscope “, Jpn. J. Appl. Phys. (2007) 5552-5555
• T. Okajima*, M. Tanaka, S. Tsukiyama, T. Kadowaki, S. Yamamoto, M. Shimomura and H. Tokumoto, “Stress relaxation of HepG2 cells measured by atomic force microscopy”, Nanotechnology 18 (2007) 084010
• T. Okajima*, X.M. Tao, H. Azehara, H. Tokumoto, “Force Spectroscopy on Single Polymer Incorporated into Polymer Gels”, J. Nanosci. Nanotech. 7, 790?795 (2007).
• H.-J. Kwon, A. Kakugo, T. Ura, T. Okajima, Y. Tanaka, H. Furukawa, Y. Osada and J.-P. Gong*, “Actin network formation by uni-directional polycation diffusion”, Langmuir 23(2007)6257-6262
• K. Hiroaki, T. Takagi, T. Okajima, M. Kinjo*, “DNA microstructure based on self-assembly of 4-Sticky-End Holiday Junctions in Aqueous Solution “, J. Nanosci. Nanotech. 7(2007)726-729.
• 岡嶋孝治、原子間力顕微鏡：多細胞系の力学物性計測の現状、生物物理（解説） 62、159-164(2022).[book]
• 岡嶋孝治、原子間力顕微鏡による発生胚皮質領域の力学測定、膜、47、269-272(2022).
• 藤井裕紀、岡嶋孝治、原子間力顕微鏡法：細胞表面近傍のナノメカニクス、表面と真空、63、437-440 (2020).[book]
• 重川秀実、吉村雅満、目良裕、岡嶋孝治、ナノ計測ー電子線・光・プローブを用いたナノ・バイオ材料の探索と評価 (ナノ学会編、近代科学社、2020).[book]
• 藤井裕紀、岡嶋孝治、AFMを用いた1細胞・細胞集団の力学物性計測、生体の科学（特集　メカノバイオロジー）、70、273-278 (2019).[book]
• 藤井裕紀、岡嶋孝治、AFMによる多細胞系の力学測定、高分子、68、656-657 (2019).[book]
• 淺川雅、岡嶋孝治、大西洋、走査型プローブ顕微鏡（日本分析化学会編、分析化学実技シリーズ機器分析編15）(2017).[book]
• 岡嶋孝治、原子間力顕微鏡による1細胞レオロジーの定量計測─細胞の個性とエルゴード性、応用物理学会誌、86、1052-1056 (2017).[book]
• 岡嶋孝治、細胞ナノレオロジー：原子間力顕微鏡法、月刊ソフトマター、 9月号 (2018).[book]
• 岡嶋孝治、高橋亮輔，原子間力顕微鏡を用いた細胞の力学特性計測（第1章・第3節）、細胞の特性計測・操作と応用（（組織工学ライブラリ－マイクロロボティクスとバイオの融合－ 1）（コロナ社） (2016)
• 岡嶋孝治，原子間力顕微鏡を用いた細胞レオロジー特性の計測（第1章・第3節）、三次元ティッシュエンジニアリング～細胞の培養・操作・組織化から品質管理、脱細胞化まで～（株式会社NTS） (2015)
• 水谷祐輔，田中良昌，田中あや，住友弘二，岡嶋孝治，イオンコンダクタンス顕微鏡：細胞膜表面の揺らぎを計測する、光学-細胞機能に迫る非染色非破壊イメージング技術、44, (6月号）(2015)
• 高橋亮輔、岡嶋孝治、原子間力顕微鏡による超高速細胞メカニクス計測技術、ケミカルエンジニヤリング（先端計測技術開発の展望:9月号）(2015)
• 岡嶋孝治，細胞の物理学：ＳＰＭによる定量計測、表面科学 35, 544-544(2014)
• 岡嶋孝治，原子間力顕微鏡による細胞力学の定量計測（解説）、検査技術 4,2-6(2014)
• 岡嶋孝治，走査プローブ顕微鏡による細胞物性測定：原子間力顕微鏡とイオンコンダクタンス顕微鏡（総説）、化学工業 64(8), 612-617(2013)
• 岡嶋孝治、水谷祐輔、１細胞レオロジー測定：原子間力顕微鏡による細胞レオロジー計測の新手法（総説）、日本生物物理学会誌「生物物理」52, 230-233 (2012)
• 岡嶋孝治、水谷祐輔、細胞力学計測のためのマイクロ加工基板を用いた原子間力顕微鏡法（研究紹介）、日本表面科学会誌「表面科学」33, 461-466 (2012)
• 岡嶋孝治、原子間力顕微鏡による細胞レオロジー測定（総説）、日本膜学会「膜」38, 76-81 (2013)
• 岡嶋孝治、実践編　プローブ顕微鏡の使い方　第2章　試料の作り方　2.5　バイオ試料の扱い, 走査プローブ顕微鏡-正しい実験とデータ解析のために必要なこと-（実験物理科学シリーズ　6）（2009.03）
• 岡嶋孝治、徳本洋志、原子間力顕微鏡による生細胞ナノレオロジー計測、日本レオロジー学会誌36(2008)81-86
• 岡嶋孝治、徳本洋志、”第１１章：固液界面ナノ領域の力学”、ナノテクのための物理入門（共立出版）日本表面科学会編集,162-177(2007)