研究業績 2016から現在まで / 平田 拓 教授

(1) 論文 (Peer-reviewed scientific journals)

  1. D. A. Komarov, A. Samouilov, H. Hirata, and J. L. Zweier. High fidelity triangular sweep of the magnetic field for millisecond range fast scan EPR imaging. Journal of Magnetic Resonance (2021). (in press)
  2. Y. Nakai, I. Yamaguchi, H. Hirata, H. M. Swartz, A. B. Flood, B. B. Williams, W. Schreiber, and M. Miyake. Effects of UV on L-band in vivo EPR dosimetry using tooth enamel. Applied Magnetic Resonance (2021). (in press) DOI: 10.1007/s00723-021-01340-3
  3. K. Kimura, N. Iguchi, H. Nakano, H. Yasui, S. Matsumoto, O. Inanami, and H. Hirata. Redox-sensitive mapping of a mouse tumor model using sparse projection sampling of electron paramagnetic resonance. Antioxidants and Redox Signaling (2021). DOI: 10.1089/ars.2021.0003, published online 13 April 2021. https://doi.org/10.1089/ars.2021.0003 (Open Access)
  4. N. J. Stewart, H. Nakano, S. Sugai, M. Tomohiro, Y. Kase, Y. Uchio, T. Yamaguchi, Y. Matsuo, T. Naganuma, N. Takeda, I. Nishimura, H. Hirata, T. Hashimoto, and S. Matsumoto. Hyperpolarized 13C MRI of fumarate metabolism by parahydrogen-induced polarization: A proof-of-concept in vivo study. ChemPhysChem (2021). DOI: 10.1002/cphc.202001038, published online 16 February 2021. https://doi.org/10.1002/cphc.202001038 (Open Access)
  5. J.-I. Park, K. Choi, C.-U. Koo, J. Oh, H. Hirata, H. M. Swartz, and S.-J. Ye. Dependence of radiation-induced signals on geometry of tooth enamel using a 1.15 GHz electron paramagnetic resonance spectrometer: Improvement of dosimetric accuracy. Health Physics, Vol. 120, No. 2, pp. 152-162 (2021). DOI: 10.1097/HP.0000000000001292, published online 15 July 2020. https://doi.org/10.1097/HP.0000000000001292
  6. A. Taguchi, S. DeVience, B. Driesschaert, V. V. Khramtsov, and H. Hirata. In vitro simultaneous mapping of the partial pressure of oxygen, pH and inorganic phosphate using electron paramagnetic resonance. Analyst (2020). doi: 10.1039/D0AN00168F, published online 26 February 2020. https://doi.org/10.1039/D0AN00168F
  7. R. Nakaoka and H. Hirata, Noise characteristics of a 750-MHz electronically tunable resonator for electron paramagnetic resonance spectroscopy, AIP Advances, Vol. 9, No. 7, article no. 075312 (2019) (7 pages). doi: 10.1063/1.5099381, published online 18 July 2019. https://doi.org/10.1063/1.5099381 (Open Access)
  8. T. Yokoyama, A. Taguchi, H. Kubota, N. J. Stewart, S. Matsumoto, I. A. Kirilyuk, and H. Hirata, Simultaneous T2* mapping of 14N- and 15N-labeled dicarboxy-PROXYLs using CW-EPR-based single-point imaging, Journal of Magnetic Resonance, Vol. 305, pp. 122-130 (2019). DOI: 10.1016/j.jmr.2019.06.012, published online 26 June 2019. http://doi.org/10.1016/j.jmr.2019.06.012
  9. D. A. Komarov, Y. Ichikawa, K. Yamamoto, N. J. Stewart, S. Matsumoto, H. Yasui, I. A. Kirilyuk, V. V. Khramtsov, O. Inanami, and H. Hirata. In vivo extracellular pH mapping of tumors using electron paramagnetic resonance. Analytical Chemistry, Vol. 90, No. 23, pp. 13938-13945 (2018). DOI: 10.1021/acs.analchem.8b03328, published online 29 October 2018. [Selected as Supplementary Journal Cover] http://doi.org/10.1021/acs.analchem.8b03328
  10. R. Nakaoka, D. A. Komarov, S. Matsumoto, and H. Hirata. Impact of the characteristic impedance of coaxial lines on the sensitivity of a 750-MHz electronically tunable EPR resonator. Applied Magnetic Resonance, Vol. 49, No. 8, pp. 853-867 (2018). DOI: 10.1007/s00723-018-1001-6, published online 31 March 2018. http://doi.org/10.1007/s00723-018-1001-6
  11. H. Sato-Akaba, M. C. Emoto, H. Hirata, and H. G. Fujii, Design and testing of a 750 MHz CW-EPR digital console for small animal imaging, Journal of Magnetic Resonance, Vol. 284, pp. 48-58 (2017). DOI: 10.1016/j.jmr.2017.09.008, published online 20 September 2017. http://dx.doi.org/10.1016/j.jmr.2017.09.008
  12. T. Amida, R. Nakaoka, D. A. Komarov, K. Yamamoto, O. Inanami, S. Matsumoto, and H. Hirata, A 750-MHz electronically tunable resonator using microstrip line couplers for electron paramagnetic resonance imaging of a mouse tumor-bearing leg, IEEE Transactions on Biomedical Engineering, Vol. 65, No. 5, pp. 1124-1132 (2018). DOI: 10.1109/TBME.2017.2743232, published online 23 August 2017. http://dx.doi.org/10.1109/TBME.2017.2743232
  13. M. Umakoshi, I. Yamaguchi, H. Hirata, N. Kunugita, B. B. Williams, H. M. Swartz, and M. Miyake, In vivo electron paramagnetic resonance tooth dosimetry: Dependence of radiation-induced signal amplitude on the enamel thickness and surface area of ex vivo human teeth, Health Physics, Vol. 113, No. 4, pp. 262-270 (2017). DOI: 10.1097/HP.0000000000000698, published online 7 August 2017. http://dx.doi.org/10.1097/HP.0000000000000698
  14. D. A. Komarov and H. Hirata, Fast backprojection-based reconstruction of spectral-spatial EPR images from projections with the constant sweep of a magnetic field, Journal of Magnetic Resonance, Vol. 281, pp. 44-50 (2017), published online 17 May 2017. http://dx.doi.org/10.1016/j.jmr.2017.05.005
  15. H. Kubota, D. A. Komarov, H. Yasui, S. Matsumoto, O. Inanami, I. A. Kirilyuk, V. V. Khramtsov, and H. Hirata, Feasibility of in vivo three-dimensional T2* mapping using dicarboxy-PROXYL and CW-EPR-based single-point imaging, Magnetic Resonance Materials in Physics, Biology and Medicine, Vol. 30, No. 3, pp. 291-298 (2017), published online 6 January 2017. http://dx.doi.org/10.1007/s10334-016-0606-8
  16. X. Wang, M. Emoto, Y. Miyake, K. Itto, S. Xu, H. Fujii, H. Hirata, and H. Arimoto, Novel blood-brain-barrier-permeable spin probe for in vivo electron paramagnetic resonance imaging, Bioorganic & Medicinal Chemistry Letters, Vol. 26, No. 20, pp. 4947-4949 (2016), published online 6 September 2016. http://dx.doi.org/10.1016/j.bmcl.2016.09.010
  17. M. Miyake, Y. Nakai, I. Yamaguchi, H. Hirata, N. Kunugita, B. B. Williams, and H. M. Swartz, In-vivo radiation doeimstry using portable L band EPR: On-site measurement of volunteers in Fukushima prefecture, Japan, Radiation Protection Dosimetry, Vol. 172, No. 1-3, pp. 248-253 (2016), published online 13 August 2016. http://dx.doi.org/10.1093/rpd/ncw214

(2) 国際会議プロシーディングス・アブストラク

  1. H. Hirata. Recent Progress in 3D Extracellular pH Mapping of Tumors Using EPR. International Conference “Magnetic Resonance−Current Status and Future perspectives” (EPR-75), p. 143, Kazan, Russia (2019). (Invited)
  2. D. A. Komarov, Y. Ichikawa, K. Yamamoto, N. J. Stewart, S. Matsumoto, H. Yasui, I. A. Kirilyuk, V. V. Khramtsov, O. Inanami, and H. Hirata. In vivo extracellular pH mapping of tumors using EPR imaging. XIth Conference of European Federation of EPR Groups (EFEPR 2019), OP11, Bratislava, Slovakia (2019).
  3. H. Hirata. In vivo three-dimensional extracellular pH mapping of tumors using EPR. Joint Conference of 21st International Society for Magnetic Resonance (ISMAR) and 15th European Magnetic Resonance Congress (EUROMAR), PS247, Berlin, Germany (2019). (Invited)
  4. A. Taguchi, S. DeVience, B. Driesschaert, V. V. Khramtsov, and H. Hirata. Simultaneous measurement of pH and partial pressure of oxygen in solutions using electron paramagnetic resonance (EPR) spectroscopy: A feasibility study by 750 MHz EPR. 47th Annual Meeting of International Society on Oxygen Transport to Tissue (ISOTT 2019), O.03-1, Albuquerque, NM, USA (2019).
  5. D. A. Komarov, Y. Ichikawa, K. Yamamoto, N. J. Stewart, S. Matsumoto, H. Yasui, I. A. Kirilyuk, V. V. Khramtsov, O. Inanami, H. Hirata. In vivo extracellular pH mapping of tumors using EPR. The Third Joint Conference of the Asia-Pacific EPR/ESR Society and The International EPR (ESR) Society (APES-IES 2018), 23rd–27th September 2018, IV19, Brisbane, Australia (2018). (Invited)
  6. D. A. Komarov, Y. Ichikawa, K. Yamamoto, N. J. Stewart, S. Matsumoto, H. Yasui, I. A. Kirilyuk, V. V. Khramtsov, O. Inanami, H. Hirata. In vivo extracellular pH mapping of tumors using electron paramagnetic resonance. 46th Annual Meeting of International Society on Oxygen Transport to Tissue (ISOTT 2018), 1st–5th July 2018, I-03, Keynote Talk, Seoul, Korea (2018). (Invited)
  7. H. Kubota, D. A. Komarov, S. Matsumoto, K. Yamamoto, H. Yasui, O. Inanami, I. A. Kirilyuk, V. V. Khramtsov, H. Hirata. Three-dimensional oxygen mapping using a pair of isotopic nitroxyl radicals and CW-EPR-based single-point imaging, EPR 2017: International Conference on Electron Paramagnetic Resonance Spectroscopy and Imaging of Biological Systems, 16th–21th July 2017, Oral Presentation 22, Morgantown, WV, USA (2017). (Invited)
  8. M. Miyake, Y. Nakai, I. Yamaguchi, H. Hirata, N. Kunugita, H. M. Swartz. In-vivo tooth dosimetry using a deployable L band EPR spectrometer, EPR 2017: International Conference on Electron Paramagnetic Resonance Spectroscopy and Imaging of Biological Systems, 16th–21th July 2017, Poster 36, Morgantown, WV, USA (2017).
  9. D. A. Komarov, H. Hirata. Fast backprojection-based reconstruction of spectral-spatial EPR images from projections with the constant sweep of a magnetic field, EPR 2017: International Conference on Electron Paramagnetic Resonance Spectroscopy and Imaging of Biological Systems, 16th–21th July 2017, Poster 44, Morgantown, WV, USA (2017).
  10. H. Kubota, H. Yasui, S. Matsumoto, O. Inanami, I. A. Kirilyuk, V. V. Khramtsov, H. Hirata. CW-EPR-based oxygen mapping technique using a pair of isotopic nitroxyl radicals, Xth International Workshop on EPR in Biology and Medicine, 2nd October–6th October 2016, Abstract Book p. 38, Krakow, Poland (2016). (Invited)
  11. H. Hirata, H. Kubota, H. Yasui, S. Matsumoto, O. Inanami, I. A. Kirilyuk, V. V. Khramtsov, Development of a CW-EPR-based oxygen-mapping technique using a pair of isotopic nitroxyl radicals, Asia-Pacific EPR/ESR Symposium 2016, 28th August–2nd September 2016, IN-05, Irkutsk, Russia (2016). (Invited)
  12. H. Hirata, H. Kubota, H. Yasui, S. Matsumoto, O. Inanami, I. A. Kirilyuk, V. V. Khramtsov, Feasibility study of a CW-EPR-based oxygen mapping technique using a pair of isotopic nitroxyl radicals, 58th Annual Rocky Mountain Conference on Magnetic Resonance (39th International EPR Symposium), Oral #178 (p. 55), Breckenridge, Colorado, USA (2016).
  13. H. Kubota, H. Yasui, S. Matsumoto, O. Inanami, I. A. Kirilyuk, V. V. Khramtsov, and H. Hirata, Characteristics of 14N- and 15N-labeled dicarboxy-PROXYLs as oxygen-sensitive probes for CW-EPR-based single-point imaging (SPI), 58th Annual Rocky Mountain Conference on Magnetic Resonance (39th International EPR Symposium), Poster #223 (p. 70), Breckenridge, Colorado, USA (2016).
  14. A. Enomoto and H. Hirata, Sensitivity improvement under parallel detection in CW-EPR imaging, Proceedings of International Society for Magnetic Resonance in Medicine (ISMRM) 23th Annual Meeting and Exhibition, p. 2428, Toronto, Canada (2015).
  15. H. Sato-Akaba and H. Hirata, Development of low field MRI system running on the same magnetic circuit used for 750 MHz CW EPR imaging system, Proceedings of International Society for Magnetic Resonance in Medicine (ISMRM) 23th Annual Meeting and Exhibition, p. 3112, Toronto, Canada (2015).

(3) 参考論文（解説記事）　なし

(4) 著書　なし

(5) 特許

  • European Patent: 2600143, Inventor: Hiroshi Hirata, Title: Continuous-wave electron spin resonance imaging, Proprietor: National University Corporation Hokkaido University (10 May 2016)
  • United States Patent: 9,121,918, Inventor: Hiroshi Hirata, Title: Image acquiring method and image acquiring apparatus, Assignee: National University Corporation Hokkaido University (September 1, 2015)
  • 特許5765715号、発明の名称・画像取得方法および画像取得装置、発明者・平田拓、出願人・国立大学法人北海道大学（出願日・2012年7月26日、登録2015年6月26日）

(6) その他

  • 2015/3　ポーランド共和国, Jagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Visiting Professor
  • 2000/5〜2016　アメリカ合衆国 Geisel School of Medicine at Dartmouth, Adjunct Assistant Professor of Radiology

教育活動

2019年度の講義担当

  • バイオイメージング特論（大学院・情報科学専攻・生体情報工学コース）＊
  • バイオエンジニアリング特論（大学院・情報科学専攻・生体情報工学コース）＊
  • 電気回路（情報エレクトロニクス学科２年生）
  • 電磁気学（情報エレクトロニクス学科２年生）
  • 情報エレクトロニクス演習（電気回路、情報エレクトロニクス学科２年生）
  • 情報学I（全学教育科目）

　　＊は分担

2018年度の講義担当

  • バイオイメージング特論（大学院・生命人間情報科学専攻）＊
  • バイオエンジニアリング特論（大学院・生命人間情報科学専攻）＊
  • 電気回路（情報エレクトロニクス学科２年生）
  • 電磁気学（情報エレクトロニクス学科２年生）
  • 情報エレクトロニクス演習（電気回路、情報エレクトロニクス学科２年生）

　　＊は分担

2017年度の講義担当

  • バイオイメージング特論（大学院・生命人間情報科学専攻）＊
  • バイオエンジニアリング特論（大学院・生命人間情報科学専攻）＊
  • 電気回路（情報エレクトロニクス学科２年生）
  • 電磁気学（情報エレクトロニクス学科２年生）
  • 情報エレクトロニクス演習（電気回路、情報エレクトロニクス学科２年生）

　　＊は分担

2016年度の講義担当

  • バイオイメージング特論（大学院・生命人間情報科学専攻）＊
  • バイオエンジニアリング特論（大学院・生命人間情報科学専攻）＊
  • 電気回路（情報エレクトロニクス学科２年生）
  • 電磁気学（情報エレクトロニクス学科２年生）
  • 情報エレクトロニクス演習（電気回路、情報エレクトロニクス学科２年生）

　　＊は分担

2015年度の講義担当

  • バイオイメージング特論（大学院・生命人間情報科学専攻）
  • バイオエンジニアリング特論（大学院・生命人間情報科学専攻）＊
  • 電気回路（情報エレクトロニクス学科２年生）
  • 電磁気学（情報エレクトロニクス学科２年生）

　　＊は分担

競争的研究資金の獲得

2019-2021
 日本学術振興会　科学研究費補助金（基盤研究B） 電子スピン共鳴分光による悪性腫瘍の酸素及びpHの三次元イメージング法の開発 (19H02146) 1,350万円（＋間接経費405万円）
2018-2021
 日本学術振興会　国際共同研究加速基金（国際共同研究強化B） マルチファンクション電子・核磁気共鳴イメージング法の開発 (18KK0304) 1,370万円（＋間接経費411万円）
2016-2017
 日本学術振興会　科学研究費補助金（挑戦的萌芽研究） 酸素分圧画像を指標とする強度変調放射線治療モデル実験 (16K12862) 280万円（＋間接経費84万円）
2014-2017
 日本学術振興会　科学研究費補助金（基盤研究A） 定量的がん研究のためのマルチパラメータ電子スピン共鳴イメージング法に関する研究 (26249057) 3,160万円（＋間接経費948万円）

 

社会活動・学会活動

  • 2018-2020　International EPR (ESR) Society, Vice President (Asia)
  • 2018-2020　International Society on Oxygen Transport to Tissue, Exective Committee member
  • 2012-2015　電子スピンサイエンス学会　理事

加入している学会

  • International Society for Magnetic Resonance in Medicine
  • International EPR (ESR) Society
  • International Society on Oxygen Transport to Tissue
  • 電子スピンサイエンス学会
  • 電子情報通信学会